
Benda Pharmaceutical, Inc. ("Benda" or the "Company") (OTCBB: BPMA), a China-based pharmaceutical company producing traditional Chinese and conventional medicines, as well as Gendicine®, the world's first commercialized gene therapy medicine for the treatment of cancer, announced today that its subsidiary SiBiono has made major strides in developing an anti-AIDS gene therapy. This marks SiBiono's and Benda's anticipated entry into the $14 billion Chinese anti-AIDS drug market.
SiBiono Partners with DNAVEC to Develop Anti-AIDS Gene Therapy
As the producer of the world's first commercialized gene therapy drug, SiBiono is acknowledged as a biopharmaceutical pioneer. In May 2007, leading Japanese gene therapy research institute DNAVEC sought out and formed a joint venture with SiBiono to develop the SeV-Gag vaccine, an anti-AIDS gene therapy treatment. DNAVEC designed and constructed the SeV-Gag vaccine several years ago and has patented it in both the United States and China. However, DNAVEC lacks the resources and experience to complete clinical trials and produce the drug on a commercial scale. Under the terms of the joint venture agreement, DNAVEC will leverage SiBiono's proven gene therapy manufacturing platform and will transfer the exclusive development and distribution rights of SeV-Gag in China to SiBiono. SiBiono will be responsible for completing the preclinical tests, clinical trials and manufacturing tests of the SeV-Gag vaccine in China. SiBiono will also seek all related Chinese State Food and Drug Administration (SFDA) approval. All scientific findings resulting from the development processes will be co-patented by both SiBiono and DNAVEC. SiBiono expects to obtain the required "New Drug Certificate" from the SFDA between 2012 and 2018.
"We deliberately selected SiBiono as our partner from hundreds of other leading biopharmaceutical firms because of its unparalleled expertise and technological superiority in developing, manufacturing and commercializing gene therapy treatments," stated DNAVEC CEO Dr. Mamoru Hasegawa. "SiBiono's demonstrated clinical success with Gendicine® is a feat no one else in the world has yet matched, and we firmly believe that the joint venture with SiBiono provides us the best opportunity to realize our dream and bring the SeV-Gag vaccine to market."
China's $14 Billion Anti-AIDS Drug Market
A 2006 study conducted by the AIDS research center in Tsinghua University, China's leading scientific research institute, revealed that more than one million Chinese patients were infected with human immunodeficiency virus (HIV). Other studies predicted that this number could grow exponentially in the next 10 years and that China, even with increased prevention education, will likely see 10 million HIV-infected patients by the end of 2010. The average annual treatment cost for American HIV patients is $20,000, while the cost for Chinese patients is only approximately $1,400. However, with more government funding allocated to the cause and the increasing wealth of the population, Chinese AIDS treatment costs are expected to rise in the coming years. But even at the current average annual cost of $1,400, the likely 10 million HIV infected patients by 2010 could create a $14 billion anti-AIDS drug market in China. Imported anti-AIDS drugs are often too expensive for typical Chinese patients, driving a need for innovative, affordable domestic drugs.
SeV-Gag Development
The development of SeV-Gag is led by Mr. Yi Zeng, who has been enlisted as the Chief Scientist for the project. Mr. Zeng is the only Chinese member of the UNAIDS Asia Pacific Leadership Forum on HIV/AIDS and Development. He is also the Chief Scientist of the Institute of Viral Disease Control and Prevention at the Chinese Center of Disease Control.